EDUCATION
RESEARCH PROJECTS
Zhigang He , Children's Hospital / Harvard Medical School
Studied the intrinsic neuronal signaling mechanisms and extrinsic inhibitory effects of myelin-associated inhibitors limiting axon regeneration in the adult central nervous system, with therapeutic implications for spinal cord injury and neurodegenerative diseases. (2002-2006)
Jeffrey Macklis , Mass. General Hospital / Harvard Medical School
Investigated the functional integration of transplanted neuroblasts within areas of targeted neuronal degeneration in adult somatosensory cortex. (2001)
Christopher Walsh , Beth-Israel Deaconess / Harvard Medical School
Examined the expression of reelin protein in the peripheral nervous system of developing mice, as well as the morphology of peripheral nerves in the reeler mouse. (2000)
Rafael Yuste , Columbia University
Employed Estimation-Maximization algorithm to deconvolve images of dendritic spines acquired using two-photon confocal microscopy. (1998-1999)
Paul Greengard , Rockefeller University
Studied the developmental regulation of synapsin III phosphorylation; Developed a transient transgene expression system in Xenopus laevis employing inverted terminal repeats from adeno-associated virus; Characterized cDNA and genomic clones for human synapsin III. (1996-1999)
PUBLICATIONS
Hodge LK, Klassen MP, Han BX, Yiu G, Hurrell J, Howell A, Rousseau G, Lemaigre F, Tessier-Lavigne M, Wang F. Retrograde BMP Signaling Regulates Trigeminal Sensory Neuron Identities and the Formation of Precise Face Maps. Neuron. 2007 Aug 16;55(4):572-86.
Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell JM, Chitnis T, Khoury SJ, He Z. Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J Neurosci. 2006 Sep 20;26(38):9794-804.
Yiu G, He Z. Glial Inhibition of CNS Axon Regeneration. Nat Rev Neurosci. 2006 Aug; 7(8):617-27.
Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans. Science. 2005 Oct 7;310(5745):106-10.
Park JB*, Yiu G*, Kaneko S, Wang J, Chang J, He Z. A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors. Neuron. 2005 Feb 3;45(3):345-51. (*these authors contribute equally)
Yiu G, He Z. Signaling mechanisms of the myelin inhibitors of axon regeneration. Curr Opin Neurobiol. 2003 Oct;13(5):545-51
Teillon SM, Yiu G, Walsh CA. Reelin is expressed in the accessory olfactory system, but is not a guidance cue for vomeronasal axons. Brain Res Dev Brain Res 2003 Feb 16;140(2):303-7
Majewska A, Yiu G, Yuste R. A custom-made two-photon microscope and deconvolution system. Pflugers Arch 2000 Dec;441(2-3):398-408
Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Haring M, Benfenati F, Greengard P. A third member of the synapsin gene family. Proc Natl Acad Sci U S A 1998 Apr 14;95(8):4667-72
MULTIMEDIA
Chasing the Axon's End: Growth and Regeneration in the CNS: research presentation at the New York Academy of Sciences (see "Multimedia").